Bub3 gene disruption in mice reveals essential mitotic spindle checkpoint function during early embryogenesis

Bub3 is a conserved component of the mitotic spindle assembly complex. The protein is essential for early development in Bub3 gene-disrupted mice, evident from their failure to survive beyond day 6.5–7.5 postcoitus (pc). Bub3 null embryos appear normal up to day 3.5 pc but accumulate mitotic errors...

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Pubblicato in:	Genes Dev
Autori principali:	Kalitsis, Paul, Earle, Elizabeth, Fowler, Kerry J., Choo, K.H. Andy
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Cold Spring Harbor Laboratory Press 2000
Soggetti:	Research Communication
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316933/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10995385/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.827500
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