Bub3 gene disruption in mice reveals essential mitotic spindle checkpoint function during early embryogenesis
Bub3 is a conserved component of the mitotic spindle assembly complex. The protein is essential for early development in Bub3 gene-disrupted mice, evident from their failure to survive beyond day 6.5–7.5 postcoitus (pc). Bub3 null embryos appear normal up to day 3.5 pc but accumulate mitotic errors...
Guardat en:
| Publicat a: | Genes Dev |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Cold Spring Harbor Laboratory Press
2000
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316933/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10995385/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.827500 |
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