The glucocorticoid receptor inhibits NFκB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain

Glucocorticoids repress NFκB-mediated activation of proinflammatory genes such as interleukin-8 (IL-8) and ICAM-1. Our experiments suggest that the glucocorticoid receptor (GR) confers this effect by associating through protein–protein interactions with NFκB bound at each of these genes. That is, we...

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Detalhes bibliográficos

Publicado no:	Genes Dev
Principais autores:	Nissen, Robert M., Yamamoto, Keith R.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Cold Spring Harbor Laboratory Press 2000
Assuntos:	Research Paper
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316928/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10995388/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.827900
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