Allele-specific genetic interactions between Prp8 and RNA active site residues suggest a function for Prp8 at the catalytic core of the spliceosome

The highly conserved spliceosomal protein Prp8 is known to cross-link the critical sequences at both the 5′ (GU) and 3′ (YAG) ends of the intron. We have identified prp8 mutants with the remarkable property of suppressing exon ligation defects due to mutations in position 2 of the 5′ GU, and all pos...

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Veröffentlicht in:	Genes Dev
Hauptverfasser:	Collins, Catherine A., Guthrie, Christine
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Cold Spring Harbor Laboratory Press 1999
Schlagworte:	Research Paper
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316919/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10444595/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.13.15.1970
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