Allele-specific genetic interactions between Prp8 and RNA active site residues suggest a function for Prp8 at the catalytic core of the spliceosome
The highly conserved spliceosomal protein Prp8 is known to cross-link the critical sequences at both the 5′ (GU) and 3′ (YAG) ends of the intron. We have identified prp8 mutants with the remarkable property of suppressing exon ligation defects due to mutations in position 2 of the 5′ GU, and all pos...
Zapisane w:
| Wydane w: | Genes Dev |
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| Główni autorzy: | , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Cold Spring Harbor Laboratory Press
1999
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316919/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10444595/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.13.15.1970 |
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