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Structural basis for autorepression of retinoid X receptor by tetramer formation and the AF-2 helix
The 9-cis-retinoic acid receptors (RXRα, RXRβ, and RXRγ) are nuclear receptors that play key roles in multiple hormone-signaling pathways. Biochemical data indicate that, in the absence of ligand, RXR can exist as an inactive tetramer and that its dissociation, induced by ligand, is important for re...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Cold Spring Harbor Laboratory Press
2000
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC316898/ https://ncbi.nlm.nih.gov/pubmed/10970886 |
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