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Structural basis for autorepression of retinoid X receptor by tetramer formation and the AF-2 helix

The 9-cis-retinoic acid receptors (RXRα, RXRβ, and RXRγ) are nuclear receptors that play key roles in multiple hormone-signaling pathways. Biochemical data indicate that, in the absence of ligand, RXR can exist as an inactive tetramer and that its dissociation, induced by ligand, is important for re...

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Udgivet i:Genes Dev
Principais autores: Gampe, Robert T., Montana, Valerie G., Lambert, Millard H., Wisely, G. Bruce, Milburn, Michael V., Xu, H. Eric
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2000
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316898/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10970886/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.802300
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