Structural basis for autorepression of retinoid X receptor by tetramer formation and the AF-2 helix

The 9-cis-retinoic acid receptors (RXRα, RXRβ, and RXRγ) are nuclear receptors that play key roles in multiple hormone-signaling pathways. Biochemical data indicate that, in the absence of ligand, RXR can exist as an inactive tetramer and that its dissociation, induced by ligand, is important for re...

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Библиографические подробности
Главные авторы: Gampe, Robert T., Montana, Valerie G., Lambert, Millard H., Wisely, G. Bruce, Milburn, Michael V., Xu, H. Eric
Формат: Artigo
Язык:Inglês
Опубликовано: Cold Spring Harbor Laboratory Press 2000
Предметы:
Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC316898/
https://ncbi.nlm.nih.gov/pubmed/10970886
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