Augmentation of Tonic GABA(A) Inhibition in Absence Epilepsy: Therapeutic Value of Inverse Agonists at Extrasynaptic GABA(A) Receptors

It is well established that impaired GABAergic inhibition within neuronal networks can lead to hypersynchronous firing patterns that are the typical cellular hallmark of convulsive epileptic seizures. However, recent findings have highlighted that a pathological enhancement of GABAergic signalling w...

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Detalles Bibliográficos
Main Authors: Errington, Adam C., Cope, David W., Crunelli, Vincenzo
Formato: Artigo
Idioma:Inglês
Publicado: Hindawi Publishing Corporation 2011
Assuntos:
Review Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3168769/
https://ncbi.nlm.nih.gov/pubmed/21912539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2011/790590
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