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γ-Hydroxybutyric Acid (GHB) Is Not an Agonist of Extrasynaptic GABA(A) Receptors

γ-Hydroxybutyric acid (GHB) is an endogenous compound and a drug used clinically to treat the symptoms of narcolepsy. GHB is known to be an agonist of GABA(B) receptors with millimolar affinity, but also binds with much higher affinity to another site, known as the GHB receptor. While a body of evid...

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Main Authors: Connelly, William M., Errington, Adam C., Crunelli, Vincenzo
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2013
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3823990/
https://ncbi.nlm.nih.gov/pubmed/24244421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0079062
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