The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs

The nonsense-mediated mRNA decay pathway is an example of an evolutionarily conserved surveillance pathway that rids the cell of transcripts that contain nonsense mutations. The product of the UPF1 gene is a necessary component of the putative surveillance complex that recognizes and degrades aberra...

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Veröffentlicht in:Genes Dev
Hauptverfasser: Czaplinski, Kevin, Ruiz-Echevarria, Maria J., Paushkin, Sergey V., Han, Xia, Weng, Youmin, Perlick, Haley A., Dietz, Harry C., Ter-Avanesyan, Michael D., Peltz, Stuart W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 1998
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316864/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9620853/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.12.11.1665
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