tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

TNFR1/Fas engagement results in the cleavage of cytosolic BID to truncated tBID, which translocates to mitochondria. Immunodepletion and gene disruption indicate BID is required for cytochrome c release. Surprisingly, the three-dimensional structure of this BH3 domain-only molecule revealed two hydr...

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Bibliografiska uppgifter
Huvudupphovsmän: Wei, Michael C., Lindsten, Tullia, Mootha, Vamsi K., Weiler, Solly, Gross, Atan, Ashiya, Mona, Thompson, Craig B., Korsmeyer, Stanley J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cold Spring Harbor Laboratory Press 2000
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC316859/
https://ncbi.nlm.nih.gov/pubmed/10950869
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