Avoiding cytotoxicity of transposases by dose-controlled mRNA delivery

The Sleeping Beauty (SB) transposase and its newly developed hyperactive variant, SB100X, are of increasing interest for genome modification in experimental models and gene therapy. The potential cytotoxicity of transposases requires careful assessment, considering that residual integration events o...

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Bibliografiske detaljer
Main Authors: Galla, Melanie, Schambach, Axel, Falk, Christine S., Maetzig, Tobias, Kuehle, Johannes, Lange, Kathrin, Zychlinski, Daniela, Heinz, Niels, Brugman, Martijn H., Göhring, Gudrun, Izsvák, Zsuzsanna, Ivics, Zoltán, Baum, Christopher
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2011
Fag:
Molecular Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3167617/
https://ncbi.nlm.nih.gov/pubmed/21609958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr384
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