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Gene amplification system based on double rolling-circle replication as a model for oncogene-type amplification

Gene amplification contributes to a variety of biological phenomena, including malignant progression and drug resistance. However, details of the molecular mechanisms remain to be determined. Here, we have developed a gene amplification system in yeast and mammalian cells that is based on double rol...

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Hlavní autoři: Watanabe, Takaaki, Tanabe, Hideyuki, Horiuchi, Takashi
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3167607/
https://ncbi.nlm.nih.gov/pubmed/21653557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr442
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