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Critical assessment of nucleic acid electrostatics via experimental and computational investigation of an unfolded state ensemble

Electrostatic forces, acting between helices and modulated by the presence of the ion atmosphere, are key determinants in the energetic balance that governs RNA folding. Previous studies have employed Poisson-Boltzmann (PB) theory to compute the energetic contribution of these forces in RNA folding....

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Main Authors: Bai, Yu, Chu, Vincent B., Lipfert, Jan, Pande, Vijay S., Herschlag, Daniel, Doniach, Sebastian
Format: Artigo
Jezik:Inglês
Izdano: 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3167486/
https://ncbi.nlm.nih.gov/pubmed/18722445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja800854u
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