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Disruption of Dicer1 induces dysregulated fetal gene expression and promotes hepatocarcinogenesis

BACKGROUND AND AIMS: Growing evidence suggests that microRNAs coordinate various biological processes in the liver. We describe experiments to address the physiological roles of these new regulators of gene expression in the liver that are as of yet largely undefined. METHODS: We disrupted Dicer, an...

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Detalhes bibliográficos
Main Authors: Sekine, Shigeki, Ogawa, Reiko, Ito, Rie, Hiraoka, Nobuyoshi, Mcmanus, Michael T, Kanai, Yae, Hebrok, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3167383/
https://ncbi.nlm.nih.gov/pubmed/19272382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2009.02.067
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