Critical role for Atm in suppressing V(D)J recombination-driven thymic lymphoma

Chromosome translocations involving T cell receptor (TCR) loci have been found in tumors from Ataxia telangiectasia (AT) patients and in mouse Atm(−/−) thymoma, suggesting the involvement of V(D)J recombination in these malignancies. By introducing a RAG-1 deficiency into Atm(−/−) mice in the presen...

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Detalhes bibliográficos

Publicado no:	Genes Dev
Principais autores:	Liao, Mai-Jing, Van Dyke, Terry
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Cold Spring Harbor Laboratory Press 1999
Assuntos:	Research Communication
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316723/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10346813/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.13.10.1246
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