Critical role for Atm in suppressing V(D)J recombination-driven thymic lymphoma
Chromosome translocations involving T cell receptor (TCR) loci have been found in tumors from Ataxia telangiectasia (AT) patients and in mouse Atm(−/−) thymoma, suggesting the involvement of V(D)J recombination in these malignancies. By introducing a RAG-1 deficiency into Atm(−/−) mice in the presen...
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| Yayımlandı: | Genes Dev |
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| Asıl Yazarlar: | , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Cold Spring Harbor Laboratory Press
1999
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316723/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10346813/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.13.10.1246 |
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