Critical role for Atm in suppressing V(D)J recombination-driven thymic lymphoma

Chromosome translocations involving T cell receptor (TCR) loci have been found in tumors from Ataxia telangiectasia (AT) patients and in mouse Atm(−/−) thymoma, suggesting the involvement of V(D)J recombination in these malignancies. By introducing a RAG-1 deficiency into Atm(−/−) mice in the presen...

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Detaylı Bibliyografya
Asıl Yazarlar: Liao, Mai-Jing, Van Dyke, Terry
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Cold Spring Harbor Laboratory Press 1999
Konular:
Research Communication
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC316723/
https://ncbi.nlm.nih.gov/pubmed/10346813
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