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Cytokine rescue of p53-dependent apoptosis and cell cycle arrest is mediated by distinct Jak kinase signaling pathways

Exposure of hematopoietic progenitors to γ-irradiation (IR) induces p53-dependent apoptosis and a p53-independent G(2)/M cell cycle arrest. These responses to DNA-damage can be inhibited by treatment with cytokine growth factors. Here we report that γ-IR-induced apoptosis and cell cycle arrest are s...

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Udgivet i:Genes Dev
Principais autores: Quelle, Frederick W., Wang, JinLing, Feng, Jian, Wang, Demin, Cleveland, John L., Ihle, James N., Zambetti, Gerard P.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 1998
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316716/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9553040/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.12.8.1099
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