Cytokine rescue of p53-dependent apoptosis and cell cycle arrest is mediated by distinct Jak kinase signaling pathways

Exposure of hematopoietic progenitors to γ-irradiation (IR) induces p53-dependent apoptosis and a p53-independent G(2)/M cell cycle arrest. These responses to DNA-damage can be inhibited by treatment with cytokine growth factors. Here we report that γ-IR-induced apoptosis and cell cycle arrest are s...

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Опубликовано в::	Genes Dev
Главные авторы:	Quelle, Frederick W., Wang, JinLing, Feng, Jian, Wang, Demin, Cleveland, John L., Ihle, James N., Zambetti, Gerard P.
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Cold Spring Harbor Laboratory Press 1998
Предметы:	Research Paper
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316716/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9553040/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.12.8.1099
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