A highly optimized DNA vaccine confers complete protective immunity against high-dose lethal lymphocytic choriomeningitis virus challenge

Protection against infection is the hallmark of immunity and the basis of effective vaccination. For a variety of reasons there is a great demand to develop new, safer and more effective vaccine platforms. In this regard, while ‘first-generation’ DNA vaccines were poorly immunogenic, new genetic ‘op...

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Detalhes bibliográficos
Main Authors: Shedlock, Devon J., Talbott, Kendra T., Cress, Christina, Ferraro, Bernadette, Tuyishme, Steven, Mallilankaraman, Karthik, Cisper, Neil J., Morrow, Matthew P., Wu, Stephan, Kawalekar, Omkar U., Khan, Amir, Sardesai, Niranjan Y., Muthumani, Karuppiah, Shen, Hao, Weiner, David B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3167034/
https://ncbi.nlm.nih.gov/pubmed/21238574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2010.12.064
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