A DNA Vaccine against Chikungunya Virus Is Protective in Mice and Induces Neutralizing Antibodies in Mice and Nonhuman Primates

Chikungunya virus (CHIKV) is an emerging mosquito-borne alphavirus indigenous to tropical Africa and Asia. Acute illness is characterized by fever, arthralgias, conjunctivitis, rash, and sometimes arthritis. Relatively little is known about the antigenic targets for immunity, and no licensed vaccine...

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Главные авторы: Mallilankaraman, Karthik, Shedlock, Devon J., Bao, Huihui, Kawalekar, Omkar U., Fagone, Paolo, Ramanathan, Aarthi A., Ferraro, Bernadette, Stabenow, Jennifer, Vijayachari, Paluru, Sundaram, Senthil G., Muruganandam, Nagarajan, Sarangan, Gopalsamy, Srikanth, Padma, Khan, Amir S., Lewis, Mark G., Kim, J. Joseph, Sardesai, Niranjan Y., Muthumani, Karuppiah, Weiner, David B.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2011
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3019110/
https://ncbi.nlm.nih.gov/pubmed/21264351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0000928
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