A DNA Vaccine against Chikungunya Virus Is Protective in Mice and Induces Neutralizing Antibodies in Mice and Nonhuman Primates

Chikungunya virus (CHIKV) is an emerging mosquito-borne alphavirus indigenous to tropical Africa and Asia. Acute illness is characterized by fever, arthralgias, conjunctivitis, rash, and sometimes arthritis. Relatively little is known about the antigenic targets for immunity, and no licensed vaccine...

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Autori principali: Mallilankaraman, Karthik, Shedlock, Devon J., Bao, Huihui, Kawalekar, Omkar U., Fagone, Paolo, Ramanathan, Aarthi A., Ferraro, Bernadette, Stabenow, Jennifer, Vijayachari, Paluru, Sundaram, Senthil G., Muruganandam, Nagarajan, Sarangan, Gopalsamy, Srikanth, Padma, Khan, Amir S., Lewis, Mark G., Kim, J. Joseph, Sardesai, Niranjan Y., Muthumani, Karuppiah, Weiner, David B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3019110/
https://ncbi.nlm.nih.gov/pubmed/21264351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0000928
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