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Overexpression of Insig-1 protects β cell against glucolipotoxicity via SREBP-1c
BACKGROUND: High glucose induced lipid synthesis leads to β cell glucolipotoxicity. Sterol regulatory element binding protein-1c (SREBP-1c) is reported to be partially involved in this process. Insulin induced gene-1 (Insig-1) is an important upstream regulator of Insig-1-SREBPs cleavage activating...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BioMed Central
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3166905/ https://ncbi.nlm.nih.gov/pubmed/21843373 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1423-0127-18-57 |
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