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Dual-mode of insulin action controls GLUT4 vesicle exocytosis

Insulin stimulates translocation of GLUT4 storage vesicles (GSVs) to the surface of adipocytes, but precisely where insulin acts is controversial. Here we quantify the size, dynamics, and frequency of single vesicle exocytosis in 3T3-L1 adipocytes. We use a new GSV reporter, VAMP2-pHluorin, and bypa...

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Autors principals: Xu, Yingke, Rubin, Bradley R., Orme, Charisse M., Karpikov, Alexander, Yu, Chenfei, Bogan, Jonathan S., Toomre, Derek K.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3166865/
https://ncbi.nlm.nih.gov/pubmed/21555461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201008135
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