Determining the contribution of NPM1 heterozygosity to NPM-ALK-induced lymphomagenesis

Heterozygous expression of Nucleophosmin (NPM1) predisposes to hematological malignancies in the mouse and cooperates with Myc in lymphomagenesis. NPM1 is therefore regarded as a haploinsufficient tumor suppressor. Heterozygous loss of NPM1 occurs as a result of the t(2;5) which generates the oncoge...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: McDuff, Fiona Kate Elizabeth, Hook, C. Elizabeth, Tooze, Reuben, Huntly, Brian J, Pandolfi, Pier Paolo, Turner, Suzanne Dawn
Format: Artigo
Langue:Inglês
Publié: 2011
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3166849/
https://ncbi.nlm.nih.gov/pubmed/21709672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/labinvest.2011.96
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires