Determining the contribution of NPM1 heterozygosity to NPM-ALK-induced lymphomagenesis

Heterozygous expression of Nucleophosmin (NPM1) predisposes to hematological malignancies in the mouse and cooperates with Myc in lymphomagenesis. NPM1 is therefore regarded as a haploinsufficient tumor suppressor. Heterozygous loss of NPM1 occurs as a result of the t(2;5) which generates the oncoge...

Full description

Saved in:

Bibliographic Details
Main Authors:	McDuff, Fiona Kate Elizabeth, Hook, C. Elizabeth, Tooze, Reuben, Huntly, Brian J, Pandolfi, Pier Paolo, Turner, Suzanne Dawn
Format:	Artigo
Language:	Inglês
Published:	2011
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3166849/ https://ncbi.nlm.nih.gov/pubmed/21709672 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/labinvest.2011.96
Tags:	Add Tag No Tags, Be the first to tag this record!

Determining the contribution of NPM1 heterozygosity to NPM-ALK-induced lymphomagenesis

Similar Items