Post-transcriptional generation of miRNA variants by multiple nucleotidyl transferases contributes to miRNA transcriptome complexity

Modification of microRNA sequences by the 3′ addition of nucleotides to generate so-called “isomiRs” adds to the complexity of miRNA function, with recent reports showing that 3′ modifications can influence miRNA stability and efficiency of target repression. Here, we show that the 3′ modification o...

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Hlavní autoři: Wyman, Stacia K., Knouf, Emily C., Parkin, Rachael K., Fritz, Brian R., Lin, Daniel W., Dennis, Lucas M., Krouse, Michael A., Webster, Philippa J., Tewari, Muneesh
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2011
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3166830/
https://ncbi.nlm.nih.gov/pubmed/21813625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.118059.110
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