Spinal neuronal NOS activation mediates sigma-1 receptor-induced mechanical and thermal hypersensitivity in mice: involvement of PKC-dependent GluN1 phosphorylation

BACKGROUND AND PURPOSE: We recently demonstrated that activation of the spinal sigma-1 receptor induces mechanical and thermal hypersensitivity via calcium-dependent second messenger cascades and phosphorylation of the spinal NMDA receptor GluN1 subunit (pGluN1). Here we examined the role of NO in t...

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Bibliografiske detaljer
Main Authors: Roh, Dae-Hyun, Choi, Sheu-Ran, Yoon, Seo-Yeon, Kang, Suk-Yun, Moon, Ji-Young, Kwon, Soon-Gu, Han, Ho-Jae, Beitz, Alvin J, Lee, Jang-Hern
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Publishing Ltd 2011
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3166697/
https://ncbi.nlm.nih.gov/pubmed/21391983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01316.x
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