The protein encoded by the proto-oncogene DEK changes the topology of chromatin and reduces the efficiency of DNA replication in a chromatin-specific manner

The structure of chromatin regulates the genetic activity of the underlying DNA sequence. We report here that the protein encoded by the proto-oncogene DEK, which is involved in acute myelogenous leukemia, induces alterations of the superhelical density of DNA in chromatin. The change in topology is...

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Vydáno v:Genes Dev
Hlavní autoři: Alexiadis, Vassilios, Waldmann, Tanja, Andersen, Jens, Mann, Matthias, Knippers, Rolf, Gruss, Claudia
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2000
Témata:
Research Communication
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316669/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10837023/
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