GTP binding to the ROC domain of DAP-kinase regulates its function through intramolecular signalling

Death-associated protein kinase (DAPk) was recently suggested by sequence homology to be a member of the ROCO family of proteins. Here, we show that DAPk has a functional ROC (Ras of complex proteins) domain that mediates homo-oligomerization and GTP binding through a defined P-loop motif. Upon bind...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Carlessi, Rodrigo, Levin-Salomon, Vered, Ciprut, Sara, Bialik, Shani, Berissi, Hanna, Albeck, Shira, Peleg, Yoav, Kimchi, Adi
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2011
Aiheet:
Scientific Reports
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3166453/
https://ncbi.nlm.nih.gov/pubmed/21738225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2011.126
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia