GTP binding to the ROC domain of DAP-kinase regulates its function through intramolecular signalling

Death-associated protein kinase (DAPk) was recently suggested by sequence homology to be a member of the ROCO family of proteins. Here, we show that DAPk has a functional ROC (Ras of complex proteins) domain that mediates homo-oligomerization and GTP binding through a defined P-loop motif. Upon bind...

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Detalhes bibliográficos
Main Authors: Carlessi, Rodrigo, Levin-Salomon, Vered, Ciprut, Sara, Bialik, Shani, Berissi, Hanna, Albeck, Shira, Peleg, Yoav, Kimchi, Adi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Scientific Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3166453/
https://ncbi.nlm.nih.gov/pubmed/21738225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2011.126
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