DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-X(L) and induction of autophagy

Autophagy, an evolutionarily conserved process, has functions both in cytoprotective and programmed cell death mechanisms. Beclin 1, an essential autophagic protein, was recently identified as a BH3-domain-only protein that binds to Bcl-2 anti-apoptotic family members. The dissociation of beclin 1 f...

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Detalhes bibliográficos
Main Authors: Zalckvar, Einat, Berissi, Hanna, Mizrachy, Liat, Idelchuk, Yulia, Koren, Itay, Eisenstein, Miriam, Sabanay, Helena, Pinkas-Kramarski, Ronit, Kimchi, Adi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
Assuntos:
Scientific Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2658558/
https://ncbi.nlm.nih.gov/pubmed/19180116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2008.246
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