Schwann cell hyperplasia and tumors in transgenic mice expressing a naturally occurring mutant NF2 protein

Specific mutations in some tumor suppressor genes such as p53 can act in a dominant fashion. We tested whether this mechanism may also apply for the neurofibromatosis type-2 gene (NF2) which, when mutated, leads to schwannoma development. Transgenic mice were generated that express, in Schwann cells...

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Hlavní autoři: Giovannini, Marco, Robanus-Maandag, Els, Niwa-Kawakita, Michiko, van der Valk, Martin, Woodruff, James M., Goutebroze, Laurence, Mérel, Philippe, Berns, Anton, Thomas, Gilles
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 1999
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC316642/
https://ncbi.nlm.nih.gov/pubmed/10215625
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