Cre-mediated germline mosaicism: a new transgenic mouse for the selective removal of residual markers from tri-lox conditional alleles

The binary Cre-lox conditional knockout system requires an essential part of the target gene to be flanked by loxP sites, enabling excision in vivo upon Cre expression. LoxP sites are introduced by homologous recombination, together with a selectable marker. However, this marker can disturb gene exp...

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Bibliografiske detaljer
Main Authors: Leneuve, Patricia, Colnot, Sabine, Hamard, Ghislaine, Francis, Fiona, Niwa-Kawakita, Michiko, Giovannini, Marco, Holzenberger, Martin
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2003
Fag:
NAR Methods Online
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC149843/
https://ncbi.nlm.nih.gov/pubmed/12595570
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