Conditional biallelic Nf2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2

Hemizygosity for the NF2 gene in humans causes a syndromic susceptibility to schwannoma development. However, Nf2 hemizygous mice do not develop schwannomas but mainly osteosarcomas. In the tumors of both species, the second Nf2 allele is inactivated. We report that conditional homozygous Nf2 knocko...

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Main Authors: Giovannini, Marco, Robanus-Maandag, Els, van der Valk, Martin, Niwa-Kawakita, Michiko, Abramowski, Vincent, Goutebroze, Laurence, Woodruff, James M., Berns, Anton, Thomas, Gilles
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2000
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC316733/
https://ncbi.nlm.nih.gov/pubmed/10887156
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