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Exploring Organosilane Amines as Potent Inhibitors and Structural Probes of Influenza A Virus M2 Proton Channel

We describe the use of organosilanes as inhibitors and structural probes of a membrane protein, the M2 proton channel from influenza A virus. Organosilane amine inhibitors were found to be generally as potent as their carbon analogs in targeting WT A/M2, and more potent against the drug resistant A/...

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Bibliografski detalji
Glavni autori: Wang, Jun, Ma, Chunlong, Wu, Yibing, Lamb, Robert A., Pinto, Lawrence H., DeGrado, William F.
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3166227/
https://ncbi.nlm.nih.gov/pubmed/21819109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja2050666
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