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Cetuximab Augments Cytotoxicity with Poly (ADP-Ribose) Polymerase Inhibition in Head and Neck Cancer

Overexpression of the epidermal growth factor receptor (EGFR) is a hallmark of head and neck cancers and confers increased resistance and inferior survival rates. Despite targeted agents against EGFR, such as cetuximab (C225), almost half of treated patients fail this therapy, necessitating novel th...

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Autors principals: Nowsheen, Somaira, Bonner, James A., LoBuglio, Albert F., Trummell, Hoa, Whitley, Alexander C., Dobelbower, Michael C., Yang, Eddy S.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3166164/
https://ncbi.nlm.nih.gov/pubmed/21912620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0024148
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