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The poly(ADP-Ribose) polymerase inhibitor ABT-888 reduces radiation-induced nuclear EGFR and augments head and neck tumor response to radiotherapy

BACKGROUND AND PURPOSE: Current therapies for head and neck cancer frequently are not curative, necessitating novel therapeutic strategies. Thus, we studied whether inhibition of poly (ADP-Ribose) polymerase (PARP), a key DNA repair enzyme, could improve efficacy of radiotherapy in human head and ne...

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Main Authors: Nowsheen, Somaira, Bonner, James A., Yang, Eddy S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3157293/
https://ncbi.nlm.nih.gov/pubmed/21719137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.radonc.2011.05.084
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