Blast-derived microvesicles in sera from patients with acute myeloid leukemia suppress natural killer cell function via membrane-associated transforming growth factor-β1

BACKGROUND: Natural killer cell cytotoxicity is decreased in patients with acute myeloid leukemia in comparison to that in normal controls. Tumor-derived microvesicles present in patients’ sera exert detrimental effects on immune cells and may influence tumor progression. DESIGN AND METHODS: We inve...

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Détails bibliographiques
Auteurs principaux: Szczepanski, Miroslaw J., Szajnik, Marta, Welsh, Ann, Whiteside, Theresa L., Boyiadzis, Michael
Format: Artigo
Langue:Inglês
Publié: Ferrata Storti Foundation 2011
Sujets:
Original Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3166100/
https://ncbi.nlm.nih.gov/pubmed/21606166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2010.039743
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