The Herpes Simplex Virus 1 Latency-Associated Transcript Promotes Functional Exhaustion of Virus-Specific CD8(+) T Cells in Latently Infected Trigeminal Ganglia: a Novel Immune Evasion Mechanism

Following ocular herpes simplex virus 1 (HSV-1) infection of C57BL/6 mice, HSV-specific (HSV-gB(498–505) tetramer(+)) CD8(+) T cells are induced, selectively retained in latently infected trigeminal ganglia (TG), and appear to decrease HSV-1 reactivation. The HSV-1 latency-associated transcript (LAT...

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Auteurs principaux: Chentoufi, Aziz A., Kritzer, Elizabeth, Tran, Michael V., Dasgupta, Gargi, Lim, Chang Hyun, Yu, David C., Afifi, Rasha E., Jiang, Xianzhi, Carpenter, Dale, Osorio, Nelson, Hsiang, Chinhui, Nesburn, Anthony B., Wechsler, Steven L., BenMohamed, Lbachir
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2011
Sujets:
Virus-Cell Interactions
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3165846/
https://ncbi.nlm.nih.gov/pubmed/21715478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00587-11
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