Inhibition of HIV-1 Tat-Mediated Transcription by a Coumarin Derivative, BPRHIV001, through the Akt Pathway

The human immunodeficiency virus type 1 (HIV-1)-encoded RNA-binding protein Tat is known to play an essential role in viral gene expression. In the search for novel compounds to inhibit Tat transactivity, one coumarin derivative, BPRHIV001, was identified, with a 50% effective concentration (EC(50))...

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Detalhes bibliográficos
Main Authors: Lin, Pi-Han, Ke, Yi-Yu, Su, Chun-Ting, Shiao, Hui-Yi, Hsieh, Hsing-Pang, Chao, Yu-Kai, Lee, Chun-Nan, Kao, Chuan-Liang, Chao, Yu-Sheng, Chang, Sui-Yuan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3165834/
https://ncbi.nlm.nih.gov/pubmed/21697490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00175-11
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