Development and Application of Hepatitis C Reporter Viruses with Genotype 1 to 7 Core-Nonstructural Protein 2 (NS2) Expressing Fluorescent Proteins or Luciferase in Modified JFH1 NS5A

To facilitate genotype-specific high-throughput studies of hepatitis C virus (HCV), we have developed reporter viruses using JFH1-based recombinants expressing core-nonstructural protein 2 (NS2) of genotype 1 to 7 prototype isolates. We introduced enhanced green fluorescent protein (EGFP) into NS5A...

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Detalhes bibliográficos
Main Authors: Gottwein, Judith M., Jensen, Tanja B., Mathiesen, Christian K., Meuleman, Philip, Serre, Stephanie B. N., Lademann, Jacob B., Ghanem, Lubna, Scheel, Troels K. H., Leroux-Roels, Geert, Bukh, Jens
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3165809/
https://ncbi.nlm.nih.gov/pubmed/21697486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00049-11
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