The TRIM5α Genotype of Rhesus Macaques Affects Acquisition of Simian Immunodeficiency Virus SIVsmE660 Infection after Repeated Limiting-Dose Intrarectal Challenge

It has recently been shown that polymorphism at the rhesus macaque TRIM5 locus can affect simian immunodeficiency virus (SIV) replication. Here we show that TRIM5 alleles can also affect acquisition of SIVsmE660. Animals coexpressing the TRIM5(TFP) and TRIM5(CypA) alleles took significantly longer t...

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Autori principali: Reynolds, Matthew R., Sacha, Jonah B., Weiler, Andrea M., Borchardt, Gretta J., Glidden, Chrystal E., Sheppard, Neil C., Norante, Francesca A., Castrovinci, Philip A., Harris, Jacqueline J., Robertson, Henry T., Friedrich, Thomas C., McDermott, Adrian B., Wilson, Nancy A., Allison, David B., Koff, Wayne C., Johnson, Welkin E., Watkins, David I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2011
Soggetti:
Virus-Cell Interactions
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3165772/
https://ncbi.nlm.nih.gov/pubmed/21734037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05074-11
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