Vectored delivery of anti-SIV envelope targeting mAb via AAV8 protects rhesus macaques from repeated limiting dose intrarectal swarm SIVsmE660 challenge

Gene based delivery of immunoglobulins promises to safely and durably provide protective immunity to individuals at risk of acquiring infectious diseases such as HIV. We used a rhesus macaque animal model to optimize delivery of naturally-arising, autologous anti-SIV neutralizing antibodies expresse...

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Dettagli Bibliografici
Pubblicato in:PLoS Pathog
Autori principali: Welles, Hugh C., Jennewein, Madeleine F., Mason, Rosemarie D., Narpala, Sandeep, Wang, Lingshu, Cheng, Cheng, Zhang, Yi, Todd, John-Paul, Lifson, Jeffrey D., Balazs, Alejandro B., Alter, Galit, McDermott, Adrian B., Mascola, John R., Roederer, Mario
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2018
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6296672/
https://ncbi.nlm.nih.gov/pubmed/30517201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007395
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