Vectored delivery of anti-SIV envelope targeting mAb via AAV8 protects rhesus macaques from repeated limiting dose intrarectal swarm SIVsmE660 challenge

Gene based delivery of immunoglobulins promises to safely and durably provide protective immunity to individuals at risk of acquiring infectious diseases such as HIV. We used a rhesus macaque animal model to optimize delivery of naturally-arising, autologous anti-SIV neutralizing antibodies expresse...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Welles, Hugh C., Jennewein, Madeleine F., Mason, Rosemarie D., Narpala, Sandeep, Wang, Lingshu, Cheng, Cheng, Zhang, Yi, Todd, John-Paul, Lifson, Jeffrey D., Balazs, Alejandro B., Alter, Galit, McDermott, Adrian B., Mascola, John R., Roederer, Mario
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6296672/
https://ncbi.nlm.nih.gov/pubmed/30517201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007395
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