Vectored delivery of anti-SIV envelope targeting mAb via AAV8 protects rhesus macaques from repeated limiting dose intrarectal swarm SIVsmE660 challenge

Gene based delivery of immunoglobulins promises to safely and durably provide protective immunity to individuals at risk of acquiring infectious diseases such as HIV. We used a rhesus macaque animal model to optimize delivery of naturally-arising, autologous anti-SIV neutralizing antibodies expresse...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:PLoS Pathog
मुख्य लेखकों: Welles, Hugh C., Jennewein, Madeleine F., Mason, Rosemarie D., Narpala, Sandeep, Wang, Lingshu, Cheng, Cheng, Zhang, Yi, Todd, John-Paul, Lifson, Jeffrey D., Balazs, Alejandro B., Alter, Galit, McDermott, Adrian B., Mascola, John R., Roederer, Mario
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Public Library of Science 2018
विषय:
Research Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6296672/
https://ncbi.nlm.nih.gov/pubmed/30517201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007395
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