Evidence for a Dual Antiviral Role of the Major Nuclear Domain 10 Component Sp100 during the Immediate-Early and Late Phases of the Human Cytomegalovirus Replication Cycle

In recent studies, the nuclear domain 10 (ND10) components PML and hDaxx were identified as cellular restriction factors that inhibit the initiation of human cytomegalovirus (HCMV) replication. The antiviral function of ND10, however, is antagonized by the IE1 protein, which induces ND10 disruption....

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Bibliographic Details
Main Authors: Tavalai, Nina, Adler, Martina, Scherer, Myriam, Riedl, Yvonne, Stamminger, Thomas
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2011
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3165758/
https://ncbi.nlm.nih.gov/pubmed/21734036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00870-11
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