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A Noncanonical Function of Polycomb Repressive Complexes Promotes Human Cytomegalovirus Lytic DNA Replication and Serves as a Novel Cellular Target for Antiviral Intervention

Chromatin-based modifications of herpesviral genomes play a crucial role in dictating the outcome of infection. Consistent with this, host cell multiprotein complexes, such as polycomb repressive complexes (PRCs), were proposed to act as epigenetic regulators of herpesviral latency. In particular, P...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Svrlanska, Adriana, Reichel, Anna, Schilling, Eva-Maria, Scherer, Myriam, Stamminger, Thomas, Reuter, Nina
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6475799/
https://ncbi.nlm.nih.gov/pubmed/30814291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02143-18
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