Azole Resistance in Aspergillus fumigatus Isolates from the ARTEMIS Global Surveillance Study Is Primarily Due to the TR/L98H Mutation in the cyp51A Gene

We surveyed 497 isolates of Aspergillus fumigatus collected from 2008 to 2009 as part of the ARTEMIS global surveillance study for elevated MIC values to itraconazole, voriconazole, and posaconazole. Sequencing of the cyp51A gene revealed that 8/29 isolates with elevated MIC values to one or more tr...

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Bibliographische Detailangaben
Hauptverfasser: Lockhart, Shawn R., Frade, João P., Etienne, Kizee A., Pfaller, Michael A., Diekema, Daniel J., Balajee, S. Arunmozhi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2011
Schlagworte:
Mechanisms of Resistance
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3165364/
https://ncbi.nlm.nih.gov/pubmed/21690285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00185-11
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