Azole Resistance in Aspergillus fumigatus Isolates from the ARTEMIS Global Surveillance Study Is Primarily Due to the TR/L98H Mutation in the cyp51A Gene

We surveyed 497 isolates of Aspergillus fumigatus collected from 2008 to 2009 as part of the ARTEMIS global surveillance study for elevated MIC values to itraconazole, voriconazole, and posaconazole. Sequencing of the cyp51A gene revealed that 8/29 isolates with elevated MIC values to one or more tr...

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Detalhes bibliográficos
Main Authors: Lockhart, Shawn R., Frade, João P., Etienne, Kizee A., Pfaller, Michael A., Diekema, Daniel J., Balajee, S. Arunmozhi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3165364/
https://ncbi.nlm.nih.gov/pubmed/21690285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00185-11
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