Indole-3-carbinol downregulation of telomerase gene expression requires the inhibition of estrogen receptor-alpha and Sp1 transcription factor interactions within the hTERT promoter and mediates the G(1) cell cycle arrest of human breast cancer cells

Indole-3-carbinol (I3C), a naturally occurring hydrolysis product of glucobrassicin from cruciferous vegetables such as broccoli, cabbage and Brussels sprouts, is an anticancer phytochemical that triggers complementary sets of antiproliferative pathways to induce a cell cycle arrest of estrogen-resp...

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Main Authors: Marconett, Crystal N., Sundar, Shyam N., Tseng, Min, Tin, Antony S., Tran, Kalvin Q., Mahuron, Kelly M., Bjeldanes, Leonard F., Firestone, Gary L.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2011
Teme:
Cancer Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3165124/
https://ncbi.nlm.nih.gov/pubmed/21693539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgr116
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