Indole-3-Carbinol Triggers Aryl Hydrocarbon Receptor-dependent Estrogen Receptor (ER)α Protein Degradation in Breast Cancer Cells Disrupting an ERα-GATA3 Transcriptional Cross-Regulatory Loop

Estrogen receptor (ER)α is a critical target of therapeutic strategies to control the proliferation of hormone-dependent breast cancers. Preferred clinical options have significant adverse side effects that can lead to treatment resistance due to the persistence of active estrogen receptors. We have...

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Main Authors: Marconett, Crystal N., Sundar, Shyam N., Poindexter, Kevin M., Stueve, Theresa R., Bjeldanes, Leonard F., Firestone, Gary L.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2847521/
https://ncbi.nlm.nih.gov/pubmed/20130088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E09-08-0689
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