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Cytotoxic activity of immunotoxin SS1P is modulated by TACE-dependent mesothelin shedding
Mesothelin is a cell-surface tumor-associated antigen expressed in several human cancers. The limited expression of mesothelin on normal tissues and its high expression in many cancers make it an attractive candidate for targeted therapies utilizing monoclonal antibodies, immunoconjugates and immuno...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3165076/ https://ncbi.nlm.nih.gov/pubmed/21775520 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-0466 |
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